منابع مشابه
Inception of Stratified Medicine
The art of predicting the results of any drug treatment has always been a topic of interest among the scientific community across the globe. Many diseases have been attributed to gene defects, giving rise to a whole new field of pharmacogenomics within the domain of clinical pharmacology. Stratified medicine is the science of associating such diseases with genetic defects and predicting the eff...
متن کاملStratified medicine for mental disorders
There is recognition that biomedical research into the causes of mental disorders and their treatment needs to adopt new approaches to research. Novel biomedical techniques have advanced our understanding of how the brain develops and is shaped by behaviour and environment. This has led to the advent of stratified medicine, which translates advances in basic research by targeting aetiological m...
متن کاملStratified Medicine and Reimbursement Issues
Stratified Medicine (SM) has the potential to target patient populations who will most benefit from a therapy while reducing unnecessary health interventions associated with side effects. The link between clinical biomarkers/diagnostics and therapies provides new opportunities for value creation to strengthen the value proposition to pricing and reimbursement (P&R) authorities. However, the int...
متن کاملStratified medicine: drugs meet genetics.
It is well recognised that genetic factors play a major role in the development of respiratory diseases such as asthma and chronic obstructive pulmonary disease. However, whilst extensive data exist on diseases caused primarily by single gene defects, such as α1-antitrypsin deficiency, the genetic factors responsible for the development of complex disease are only now being defined. Once the ge...
متن کاملTowards Stratified Medicine in Plasma Cell Myeloma
Plasma cell myeloma is a clinically heterogeneous malignancy accounting for approximately one to 2% of newly diagnosed cases of cancer worldwide. Treatment options, in addition to long-established cytotoxic drugs, include autologous stem cell transplant, immune modulators, proteasome inhibitors and monoclonal antibodies, plus further targeted therapies currently in clinical trials. Whilst treat...
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ژورنال
عنوان ژورنال: The Biochemist
سال: 2016
ISSN: 0954-982X,1740-1194
DOI: 10.1042/bio03801019